High Frequency, Short Latency Disinhibition Bursting of Midbrain
نویسندگان
چکیده
1 Dopaminergic Neurons 2 3 Abbreviated Title: Disinhibition of Dopaminergic Neurons 4 5 6 Collin J. Lobb, Charles J. Wilson and Carlos A. Paladini 7 Neurosciences Institute 8 University of Texas at San Antonio 9 San Antonio, TX 78249 UTSA 10 11 Corresponding Author: 12 Carlos A. Paladini ([email protected]) 13 Department of Biology 14 University of Texas at San Antonio 15 One UTSA Circle 16 San Antonio, TX 78249 USA 17 18 Acknowledgements: This work was supported by MH084494 (CJL), MH079276, and 19 NS060658 (CAP). 20 Articles in PresS. J Neurophysiol (March 2, 2011). doi:10.1152/jn.01076.2010
منابع مشابه
High-frequency, short-latency disinhibition bursting of midbrain dopaminergic neurons.
During reinforcement and sequence learning, dopaminergic neurons fire bursts of action potentials. Dopaminergic neurons in vivo receive strong background excitatory and inhibitory inputs, suggesting that one mechanism by which bursts may be produced is disinhibition. Unfortunately, these inputs are lost during slice preparation and are not precisely controlled during in vivo experiments. In the...
متن کاملHow visual stimuli activate dopaminergic neurons at short latency.
Unexpected, biologically salient stimuli elicit a short-latency, phasic response in midbrain dopaminergic (DA) neurons. Although this signal is important for reinforcement learning, the information it conveys to forebrain target structures remains uncertain. One way to decode the phasic DA signal would be to determine the perceptual properties of sensory inputs to DA neurons. After local disinh...
متن کاملAn intrinsic neuronal oscillator underlies dopaminergic neuron bursting.
Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for diseases affected by altered bursting, a mechanistic understanding of bursting is essential. Our results show that bursting is initiated by a speci...
متن کاملActivation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons.
We examined the role of excitatory amino acids (EAAs) in the activation of midbrain dopaminergic (DA) neurons evoked by stimulation of the ventromedial and ventrolateral (subcommissural) bed nucleus of the stria terminalis (vBNST). Using anesthetized rats and extracellular recording techniques, we found that 84.8% of ventral tegmental area (VTA) DA neurons were activated synaptically by single-...
متن کاملRole of the electrogenic Na/K pump in disinhibition-induced bursting in cultured spinal networks.
Disinhibition-induced bursting activity in cultures of fetal rat spinal cord is mainly controlled by intrinsic spiking with subsequent recurrent excitation of the network through glutamate synaptic transmission, and by autoregulation of neuronal excitability. Here we investigated the contribution of the electrogenic Na/K pump to the autoregulation of excitability using extracellular recordings ...
متن کامل